The overarching objective of the Morphology Core, under the Directorship of Dr. Silberg, is to enhance the ability of the Program Project Leaders and their personnel to perform research utilizing morphologic techniques. The Morphology Core fulfills these through the following interrelated services, all of which have had historical success throughout the University of Pennsylvania. 2. Support Program Project Investigators through instruction of techniques and providing the reagents necessary to perform morphologic analysis of tissues and cells. 1. Provide a meticulously organized technical service to the Program Project Investigators. The Core processes, embeds, cuts and hematoxylin/eosin stains frozen and paraffin mouse and human tissues. The Core also performs special immunohistochemistry for Investigators on cut tissue.